Studies hinein laboratory animals have shown that barbiturates cause reduction rein the tone and contractility of the uterus, ureters, and urinary bladder. However, concentrations of the drugs required to produce this effect rein humans are not reached with sedative-hypnotic doses.
An occasional dog may elicit reflex responses manifested by motor movement; however, an unconscious animal does not experience pain, because the cerebral cortex is not functioning.
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There are no data on pregnancy exposures rein primates corresponding to periods prior to the third trimester rein humans.
Caution should be exercised to avoid contact of the drug with open wounds or accidental self-inflicted injections. Keep out of reach of children. If eye contact, flush with water and seek medical advice/attention. PRECAUTIONS
Pharmacokinetics: Barbiturates are absorbed rein varying degrees following oral, rectal, or parenteral administration. The salts are more rapidly absorbed than are the acids. The onset of action for oral or rectal administration varies from 20 to 60 minutes. For In dem administration, the onset of action is slightly faster. Following IV administration, the onset of action ranges from almost immediately for pentobarbital sodium to 5 minutes for phenobarbital sodium. Maximal CNS depression may not occur until 15 minutes or more after IV administration for phenobarbital sodium. Duration of action, which is related to the rate at which the barbiturates are redistributed throughout the body, varies among persons and rein the same person from time to time. No studies have demonstrated that the different routes of administration are equivalent with respect to bioavailability. Barbiturates are weak acids that are absorbed and rapidly distributed to all tissues and fluids with high concentrations hinein the brain, liver, and kidneys. Lipid solubility of the barbiturates is the dominant factor rein their Austeilung within the body. The more lipid soluble the barbiturate, the more rapidly it penetrates all tissues of the body. Barbiturates are bound to more info plasma and tissue proteins to a varying degree with the degree of binding increasing directly as a function of lipid solubility.
This is not a complete Tücke of all side effects or adverse reactions that may occur from the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may also report side effects or health problems to the FDA at 1-800-FDA-1088.
Use of sedative doses during Laboratorium does not impair uterine activity, however, full anesthetic dose can decrease the force and frequency of uterine contractions.
When administered intravenously, phenytoin sodium produces toxic signs of cardiovascular collapse and/or central nervous Struktur depression. Hypotension occurs when the drug is administered rapidly.
This medicine may Beryllium used for other purposes; ask your health care provider or pharmacist if you have questions. How should I use this medication?
pentobarbital will decrease the level or effect of lorlatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.